About Eosinophilic Diseases


A group of uncommon chronic illnesses, eosinophil (E-0-’si-n-o-’fil) associated diseases, are rapidly emerging as a healthcare problem worldwide.  Yet, many patients suffering from there diseases go undiagnosed for years due to a lack of information or awareness of these diseases.











* High numbers of eosinophils accumulate in body tissues causing inflammation 
and damage.
* Classified by body tissue where eosinophils accumulate.
* Diagnosed and monitored by tissue biopsies.
* Chronic diseases requiring long term treatment, with no known cure.
* Debilitating diseases leading to missed work, school, social outings.
* Delays in diagnosis are common.
Eosinophilic Esophagitis
* Causes inflammation and damage to the esophagus, affecting the ability
to eat
* Estimated prevalence of more than 1 per 2000
* Increase in new cases (2 – 10 fold) over the past 10 years
* Patients may depend on steroids or medical nutrition therapy through
a feeding tube


Eosinophilic Gastroenteritis (EGE) and Eosinophilic Gastritis (EG)
     *  Causes inflammation and damage to the stomach and/or small intestine, often
         misdiagnosed

     *  Estimate prevalence of EGE and EC combined is 1 per 3500
     *  Causes severe abdominal pain, forceful vomiting and/or diarrhea

     *  Treatment may involve a limited diet, feeding tube and/or steriods


Eosinophilic Colitis (EC)
     *  Causes inflammation and damage to the large intestine (colon)
     *  May be misdiagnosed as Irritable Bowel Syndrome (IBS) or Inflammatory bowel
        disease
     *  Patients may require restricted diet therapy, elemental formula or chronic steroids


Hypereosinophilic Syndrome (HES)
     *  Diagnosed by very high number of eosinophils in the blood and tissue

     *  Causes potentially fatal damage to one or more organs in the body (heart, lungs,
         gut, skin)


Churg-Strauss Syndrome (CSS)
     *  Eosinophils cause damage to small to medium blood vessels (vasculitis)
     *  Patient may be initally be diagnosed with severe asthma

     *  Causes potentially fatal lung, heart, brain or gastrointestinal damage
     *  Estimated to be 60-80 cases / million asthmatics / year.

Can you say EOSINOPHILIC?

E - O - sin - O - phil - ik

© American Partnership for Eosinophilic Disorders
All rights reserved.  Updated 06-01-2011

www.apfed.org
Used with permission.

What is an Eosinophil?
     
     A type of white blood cell associated with allergies, parasites, and cancers.



What are Eosinophil Associated Diseases?